What is an innocuous phrase that causes a disproportionate response?

I ask this question because I remember being totally shocked the first time I told a friend to relax about something (obviously not anything that was a big deal) and them going ballistic. I didn’t mean it (didn’t even know it could be taken as such) in a derogatory, condescending or offensive way, I literally was just trying to be soothing and supportive ironically. I since learned that saying relax or chill out really offends some people. It’s never been the case for me, but I sure am careful now…